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Curr Med Chem. 2017 Dec 5. doi: 10.2174/0929867325666171206101945. [Epub ahead of print]

Preventive and Therapeutic potentials of Anthocyanins in diabetes and associated complications.

Author information

1
Pharmacology division, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, Andhra Pradesh. India.
2
Institute of Science, GITAM University - Department of Biochemistry and Bioinformatics Vishakhapatnam. India.
3
University College of Pharmaceutical Sciences, Andhra University - Pharmacology Division Andhra Pradesh. India.
4
Center for Emerging Technologies, Jain Global Campus, Jain University - Toxinology/Toxicology and Drug Discovery Unit Karnataka. India.
5
Metabolomics & Enzymology Unit, Fundamental and Applied Biology Group, King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589. Saudi Arabia.
6
Federal University of Paraiba, Campus I 58051-970, Joao Pessoa, PB. Brazil.
7
King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589. Saudi Arabia.
8
Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota D.C.. Colombia.
9
Department of Biochemistry, Sri Krishnadevaraya University, Anantapuramu- 515 003(A.P). India.
10
Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad 500 046. India.
11
Department of Pharmacology of Pharmaceutical Faculty, I.M. Sechenov First Moscow State Medical University, Moscow. Russian Federation.
12
Department of Biotechnology, Institute of Technology, GITAM University, Vishakhapatnam-530045, A.P.. India.
13
GALLY" International Biomedical Research Consulting LLC, San Antonio, TX 78229. United States.

Abstract

Diet is an essential factor affecting the development of and risk for diabetes mellitus. In search of preventative and therapeutic strategies, it is to be considering the potential role of certain foods and their bioactive compounds to prevent the pathogenesis associated with metabolic diseases. Human consumption of anthocyanins is among the highest of all flavonoids. Epidemiological studies have suggested that the consumption of anthocyanins lowers the risk of diabetes and diabetic complications. Anthocyanins are important natural bioactive pigments responsible for red to blue colour of fruits, leaves, seeds, stems and flowers, which are present in a variety of plant species particularly in berries and cherries. A large number of bioactive anthocyanins, such as cyanidin, malvidin, delphinidin, pelargonidin, peonidin, petunidin and their metabolites have shown multiple biological activities with apparent effects on glucose absorption, glucose uptake, insulin secretion and sensitivity, on the enzymes involved in glucose metabolism, gene expressions, inflammatory mediators, glucose transporters in progression of diabetes and associated complications, such as diabetic retinopathy, nephropathy, neuropathy and diabetic vascular diseases. The versatility of the anthocyanins provides a promising approach for diabetes management than synthetic drugs. Here we summarize effect of several anthocyanins on many in vitro, in vivo and clinical studies and also reveals the mechanisms which could prevent or reverse the underlying mechanisms of diabetic pathologies including promotion of antioxidant, anti-hyperlipidemic, anti-inflammatory and anti-apoptotic activities.

KEYWORDS:

Anthocyanins; Complications; Diabetes Mellitus; Glucose

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