Format

Send to

Choose Destination
Acta Neuropathol. 2018 Feb;135(2):201-212. doi: 10.1007/s00401-017-1791-x. Epub 2017 Nov 22.

Neuropathology of iatrogenic Creutzfeldt-Jakob disease and immunoassay of French cadaver-sourced growth hormone batches suggest possible transmission of tauopathy and long incubation periods for the transmission of Abeta pathology.

Author information

1
Inserm U1127, CNRS UMR 7225, UPMC Univ Paris VI UMR S 1127, Institut du Cerveau et de la Moelle épinière, Sorbonne Universités, 47 boulevard de l'Hôpital, 75013, Paris, France. charles.duyckaerts@aphp.fr.
2
Laboratoire de Neuropathologie R. Escourolle, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France. charles.duyckaerts@aphp.fr.
3
Inserm U1127, CNRS UMR 7225, UPMC Univ Paris VI UMR S 1127, Institut du Cerveau et de la Moelle épinière, Sorbonne Universités, 47 boulevard de l'Hôpital, 75013, Paris, France.
4
Laboratoire de Neuropathologie R. Escourolle, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
5
Laboratory of Histology, Neuroanatomy and Neuropathology, Faculty of Medicine, ULB Neuroscience Institute, Université Libre de Bruxelles, Brussels, Belgium.
6
Service de Biochimie et Biologie Moléculaire, Hôpital Lariboisière, AP-HP, Paris, France.
7
Commissariat à l'Energie Atomique, DRF/iMETI/SEPIA, Fontenay-aux-Roses, France.
8
Laboratoire de Biochimie Protéomique Clinique, CHU de Montpellier, CRB, INSERM U1183, Université de Montpellier, Montpellier, France.
9
Hôpital de la Pitié-Salpêtrière, Cellule nationale de référence des MCJ, AP-HP, Paris, France.
10
Inserm U1127, CNRS UMR 7225, UPMC Univ Paris VI UMR S 1127, Institut du Cerveau et de la Moelle épinière, Sorbonne Universités, 47 boulevard de l'Hôpital, 75013, Paris, France. stephane.haik@upmc.fr.
11
Laboratoire de Neuropathologie R. Escourolle, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France. stephane.haik@upmc.fr.
12
Hôpital de la Pitié-Salpêtrière, Cellule nationale de référence des MCJ, AP-HP, Paris, France. stephane.haik@upmc.fr.

Abstract

Abeta deposits and tau pathology were investigated in 24 French patients that died from iatrogenic Creutzfeldt-Jakob disease after exposure to cadaver-derived human growth hormone (c-hGH) in the 1980s. Abeta deposits were found only in one case that had experienced one of the longest incubation periods. Three cases had also intracellular tau accumulation. The analysis of 24 batches of c-hGH, produced between 1974 and 1988, demonstrated for the first time the presence of Abeta and tau contaminants in c-hGH (in 17 and 6 batches, respectively). The incubation of prion disease was shorter in the French patients than the incubation times reported in two previously published British series. We interpreted the low incidence of Abeta in this French series as a consequence of the shorter incubation period observed in France, as compared to that observed in the United Kingdom. This concept suggested that a mean incubation period for the development of detectable Abeta deposits would be longer than 18 years after the first exposure. Moreover, we hypothesized that tau pathology might also be transmissible in humans.

KEYWORDS:

Abeta pathology; Alzheimer’s disease; Creutzfeldt–Jakob disease; Growth hormone; Prions; Tau pathology; Transmission

PMID:
29209767
DOI:
10.1007/s00401-017-1791-x

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center