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Nat Commun. 2017 Dec 5;8(1):1929. doi: 10.1038/s41467-017-01499-z.

Diffusion of treatment in social networks and mass drug administration.

Author information

1
Department of Land Economy, University of Cambridge, 19 Silver St., Cambridge, CB3 9EP, UK. gjc36@cam.ac.uk.
2
Department of Pathology, University of Cambridge, Tennis Ct. Rd., Cambridge, CB2 1QP, UK. gjc36@cam.ac.uk.
3
Department of Land Economy, University of Cambridge, 19 Silver St., Cambridge, CB3 9EP, UK. ak219@cam.ac.uk.
4
Department of Land Economy, University of Cambridge, 19 Silver St., Cambridge, CB3 9EP, UK.
5
Development Economics Group, Wageningen University, Hollandseweg 1, Wageningen, 6706 KN, The Netherlands.
6
Schistosomiasis Control Initiative, Imperial College London, Norfolk Pl., London, W2 1PG, UK.
7
Uganda Ministry of Health, Vector Control Division, Bilharzia and Worm Control Programme, 15 Bombo Rd., Kampala, Uganda.
8
Department of Pathology, University of Cambridge, Tennis Ct. Rd., Cambridge, CB2 1QP, UK.

Abstract

Information, behaviors, and technologies spread when people interact. Understanding these interactions is critical for achieving the greatest diffusion of public interventions. Yet, little is known about the performance of starting points (seed nodes) for diffusion. We track routine mass drug administration-the large-scale distribution of deworming drugs-in Uganda. We observe friendship networks, socioeconomic factors, and treatment delivery outcomes for 16,357 individuals in 3491 households of 17 rural villages. Each village has two community medicine distributors (CMDs), who are the seed nodes and responsible for administering treatments. Here, we show that CMDs with tightly knit (clustered) friendship connections achieve the greatest reach and speed of treatment coverage. Importantly, we demonstrate that clustering predicts diffusion through social networks when spreading relies on contact with seed nodes while centrality is unrelated to diffusion. Clustering should be considered when selecting seed nodes for large-scale treatment campaigns.

PMID:
29208898
PMCID:
PMC5717046
DOI:
10.1038/s41467-017-01499-z
[Indexed for MEDLINE]
Free PMC Article

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