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Cancer Discov. 2017 Dec;7(12):1371-1373. doi: 10.1158/2159-8290.CD-17-1084.

CNS Endothelial Cell Activation Emerges as a Driver of CAR T Cell-Associated Neurotoxicity.

Author information

1
Stanford Cancer Institute, Stanford University, Stanford, California. cmackall@stanford.edu dmiklos@stanford.edu.
2
Department of Pediatrics, Hematology-Oncology, Stanford University, Stanford, California.
3
Department of Medicine, Blood and Marrow Transplantation, Stanford University, Stanford, California.

Abstract

<b/> Central nervous system (CNS) toxicity associated with chimeric antigen receptor-based therapeutics has emerged as a significant cause of morbidity and mortality, and insights into the pathophysiology of this syndrome have been lacking. A new study provides evidence that cytokine-induced CNS endothelial cell activation leading to disruption of the blood-brain barrier plays an early and critical role in this phenomenon. These insights provide new opportunities for targeted therapeutic interventions to modulate endothelial cell activation. Cancer Discov; 7(12); 1371-3. ©2017 AACRSee related article by Gust et al., p. 1404.

PMID:
29208775
DOI:
10.1158/2159-8290.CD-17-1084
[Indexed for MEDLINE]
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