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Exp Cell Res. 2018 Jan 15;362(2):378-385. doi: 10.1016/j.yexcr.2017.11.039. Epub 2017 Dec 5.

MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1.

Author information

1
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai 200025, China.
2
Institute of Health Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences/Chinese Academy of Sciences & Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai, China.
3
Department of General Surgery, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
4
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai 200025, China. Electronic address: heming@shsmu.edu.cn.
5
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai 200025, China. Electronic address: zhoucx@sibs.ac.cn.

Abstract

MicroRNAs (miRNAs) play critical roles in breast cancer cell biological processes, including proliferation and apoptosis by inhibiting the expression of their target genes. Herein, we reported that miR-630 overexpression initiates apoptosis, blocks cell cycle progression and suppresses cell proliferation in breast cancer cells. Furthermore, BMI1, a member of polycomb group family, was identified as a direct target of miR-630, and there was a negative correlation between the expression levels of BMI1 and miR-630 in human breast cancer samples. With a series of biology approaches, subsequently, we proved that BMI1 was a functional downstream target of miR-630 and mediated the property of miR-630-dependent inhibition of breast cancer progression. Taken together, these findings provide further evidence on the tumor-suppression function of miR-630 in breast cancer, and clarify BMI1 as a novel functional target gene of miR-630.

KEYWORDS:

Apoptosis; BMI1; Breast cancer; miR-630

PMID:
29208462
DOI:
10.1016/j.yexcr.2017.11.039
[Indexed for MEDLINE]

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