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Phytochemistry. 2018 Feb;146:16-24. doi: 10.1016/j.phytochem.2017.11.008. Epub 2017 Dec 22.

Phytochemical variation among the traditional Chinese medicine Mu Dan Pi from Paeonia suffruticosa (tree peony).

Author information

1
Key Laboratory of Plant Resources/Beijing Botanical Garden, Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, China.
2
Key Laboratory of Plant Resources/Beijing Botanical Garden, Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, China; University of Chinese Academy of Sciences, Beijing 100049, China.
3
Key Laboratory of Plant Resources/Beijing Botanical Garden, Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, China. Electronic address: liuzhengan@ibcas.ac.cn.
4
Key Laboratory of Plant Resources/Beijing Botanical Garden, Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: wanglsh@ibcas.ac.cn.

Abstract

Mu Dan Pi is a traditional Chinese medicine used to treat inflammation, cancer, allergies, diabetes, angiocardiopathy, and neurodegenerative diseases. In this study, the metabolome variation within Mu Dan Pi collected from 372 tree peony cultivars was systematically investigated. In total, 42 metabolites were identified, comprising of 14 monoterpene glucosides, 11 tannins, 8 paeonols, 6 flavonoids, and 3 phenols. All cultivars revealed similar metabolite profiles, however, they were further classified into seven groups on the basis of their varying metabolite contents by hierarchical cluster analysis. Traditional cultivars for Mu Dan Pi were found to have very low metabolite contents, falling into clusters I and II. Cultivars with the highest amounts of metabolites were grouped in clusters VI and VII. Five potential cultivars, namely, 'Bai Yuan Qi Guan', 'Cao Zhou Hong', 'Da Zong Zi', 'Sheng Dan Lu', and 'Cheng Xin', with high contents of monoterpene glycosides, tannins, and paeonols, were further screened. Interestingly, the majority of investigated cultivars had relatively higher metabolite contents compared to the traditional medicinal tree peony cultivars.

KEYWORDS:

1,2,3,4,6-Penta-O-galloyol-β-D-glucose (PubChem CID: 65238); Apiopaeonoside (PubChem CID: 46883331); Flavonoid; Galloyloxypaeoniflorin (PubChem CID: 101636348); Metabolomics; Monoterpene glycoside; Mu Dan Pi; Oxypaeoniflorin (PubChem CID: 21631105); Paeonia; Paeoniflorin (PubChem CID: 442534); Paeonol; Paeonol (PubChem CID: 11092); Paeonolide (PubChem CID: 442923); Paeonoside (PubChem CID: 52952637); Tannin; UPLC

PMID:
29207319
DOI:
10.1016/j.phytochem.2017.11.008
[Indexed for MEDLINE]

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