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PLoS One. 2017 Dec 5;12(12):e0189074. doi: 10.1371/journal.pone.0189074. eCollection 2017.

Zingerone alleviates the delayed ventricular repolarization and AV conduction in diabetes: Effect on cardiac fibrosis and inflammation.

Author information

1
Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia and Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
2
Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah and Faculty of Applied Sciences, Umm AL-Qura University, Makkah, Saudi Arabia.
3
Department of Pharmacology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
4
Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
5
Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
6
Department of Pediatric, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
7
Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
8
Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom.

Abstract

BACKGROUND:

The study aims to analyse the action of zingerone in diabetes-related cardiac arrhythmias.

METHODS:

Diabetes was induced by streptozocin while treatment groups received 20 mg/kg zingerone daily. Following extra seven weeks, electrocardiography, extraction of blood, urine and heart for biochemical analysis, histopathology and immunofluorescence were undertaken.

RESULTS:

The suppression of QT and QTc prolongation in diabetic rats was indicative of prolonged cardiac repolarisation that was greatly reduced by zingerone treatment. In addition, the reduction in PR interval attested that zingerone improved AV delay in diabetic rats. The fibrogenic transforming growth factor β1 upregulation in diabetic hearts was suppressed by zingerone. The marked glycogen deposition and muscle degeneration seen in diabetic heart sections were also alleviated by zingerone. Furthermore, zingerone prevented the decrease in of the serum anti-inflammatory cytokine adiponectin in diabetics. The heightened levels of oxidative stress markers 8-isoprostane and uric acid in diabetic rats were suppressed. In the diabetic heart, the reduced catalase activity was improved and the excessive expression of angiotensin receptor 1 was inhibited by zingerone.

CONCLUSION:

Cardiac delayed repolarisation and AV conduction in rats with diabetes were halted by zingerone. It appears that inhibition of cardiac fibrosis and associated inflammation-oxidative stress signalling underpins the zingerone effect.

PMID:
29206854
PMCID:
PMC5716606
DOI:
10.1371/journal.pone.0189074
[Indexed for MEDLINE]
Free PMC Article

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