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Appl Physiol Nutr Metab. 2018 Apr;43(4):419-422. doi: 10.1139/apnm-2017-0506. Epub 2017 Dec 5.

A high-fat diet is deleterious to mice under glycolysis restriction.

Author information

1
Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.

Abstract

It is debated whether carbohydrate restriction has metabolic advantage for its variable weight loss. Five-week-old male mice fed a high-fat diet and receiving a glycolytic inhibitor, 2-deoxyglucose, died within 9 days. They exhibited greater decreases in rectal temperature, appetite, and decline in body weight accompanied by increasing total cholesterol level than the other groups. This study suggests that carbohydrate is necessary for adequate physical and metabolic performance when lipid-rich diet is loaded.

KEYWORDS:

acidoc├ętose; dehydration; d├ęshydratation; ketoacidosis; low-carbohydrate; restriction en sucres

PMID:
29206484
DOI:
10.1139/apnm-2017-0506
[Indexed for MEDLINE]

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