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Biomolecules. 2017 Dec 5;7(4). pii: E80. doi: 10.3390/biom7040080.

Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health.

Author information

1
College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia. drzohaibkhurshid@gmail.com.
2
Department of Preventive Dentistry, College of Dentistry, Dar-Al-Uloom University, Riyadh 13314, Saudi Arabia. m.naseem@dau.edu.sa.
3
Department of Preventive Dental Sciences, College of Dentistry, King Faisal University, Al-Ahsa 312982, Saudi Arabia. fasiri@kfu.edu.sa.
4
Department of Orthodontics, Islamic International Dental College, Ripah International University, Islamabad 44000, Pakistan. drmariahmali@gmail.com.
5
Department of Oral Pathology, College of Dentistry, Baqai University, Super Highway, P.O. Box 2407, Karachi 74600, Pakistan. rabia.sannam@baqai.edu.pk.
6
Department of Oral Medicine, Islamabad Dental Hospital (IDH), Islamabad 74700, Pakistan. Haafsa.OralMed16@iideas.edu.pk.
7
Department of Dental Materials, College of Dentistry, Taibah University, Madinah Munawwarah 41311, Saudi Arabia. mzafar@taibahu.edu.sa.
8
Department of Dental Materials, Islamic International Dental College, Riphah International University, Islamabad 44000, Pakistan. mzafar@taibahu.edu.sa.
9
National Center for Proteomics, Karachi University, Karachi 75270, Pakistan. farazmoin@hotmail.com.
10
Department of Oral Pathology, Institute of Dentistry, Liaquat University of Medical and Health Sciences, Jamshoro 71000, Pakistan. erumkhan_2010@icloud.com.

Abstract

Cathelicidins are a group of oral antimicrobial peptides that play multiple vital roles in the human body, such as their antimicrobial (broad spectrum) role against oral microbes, wound healing, and angiogenesis, with recent evidences about their role in cancer regulation. Cathelicidins are present in humans and other mammals as well. By complex interactions with the microenvironment, it results in pro-inflammatory effects. Many in vitro and in vivo experiments have been conducted to ultimately conclude that these unique peptides play an essential role in innate immunity. Peptides are released in the precursor form (defensins), which after cleavage results in cathelicidins formation. Living in the era where the major focus is on non-invasive and nanotechnology, this ultimately leads to further advancements in the field of salivaomics. Based on current spotlight innovations, we have highlighted the biochemistry, mode of action, and the importance of cathelicidins in the oral cavity.

KEYWORDS:

antimicrobial peptides; cathelicidins; diagnosis; drug; oral health; proteins

PMID:
29206168
PMCID:
PMC5745462
DOI:
10.3390/biom7040080
[Indexed for MEDLINE]
Free PMC Article

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