Format

Send to

Choose Destination
Cancer Causes Control. 2018 Feb;29(2):269-277. doi: 10.1007/s10552-017-0993-9. Epub 2017 Dec 4.

Trends in prostate cancer incidence between 1996 and 2013 in two Swiss regions by age, grade, and T-stage.

Author information

1
Cancer Registry Zurich and Zug, University Hospital Zurich, Vogelsangstrasse 10, 8091, Zurich, Switzerland. miriam.wanner@uzh.ch.
2
Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 82, 8001, Zurich, Switzerland. miriam.wanner@uzh.ch.
3
Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 82, 8001, Zurich, Switzerland.
4
Cancer Registry Zurich and Zug, University Hospital Zurich, Vogelsangstrasse 10, 8091, Zurich, Switzerland.
5
Ticino Cancer Registry, Institute of Pathology, Via in Selva 24, 6600, Locarno, Switzerland.
6
National Institute for Cancer Epidemiology and Registration (NICER), Hirschengraben 82, 8001, Zurich, Switzerland.

Abstract

PURPOSE:

To investigate differences in prostate cancer incidence between two distinct Swiss regions from 1996 to 2013 stratified by age group, grade, and T-stage.

METHODS:

The dataset included 17,495 men living in Zurich and 3,505 men living in Ticino, diagnosed with prostate cancer between 1996 and 2013. We computed age-standardized incidence rates per 100,000 person-years using the European Standard Population. Trends were assessed using JoinPoint regression analysis Software.

RESULTS:

Age-standardized incidence rates were generally higher in Zurich compared to Ticino but the difference decreased over time. Incidence rates increased significantly up to 2002 in Zurich and 2007 in Ticino and then decreased. A statistically significant increase was observed for men aged < 65 years, for grade 3 tumors, and for T-stage 2 and 3 tumors. The largest decrease was seen for grade 1 tumors. Furthermore, the incidence of tumors of unknown grade or T-stage decreased significantly in both regions.

CONCLUSIONS:

The trends in prostate cancer incidence rates were similar in both regions, although on a higher level in Zurich compared to Ticino. However, the difference decreased over time. The distribution of T-stage and grade did not explain the difference in incidence rates. Different use of opportunistic screening may play a role.

KEYWORDS:

Grading; Prostate cancer; Staging; Switzerland; Time trend

PMID:
29204913
DOI:
10.1007/s10552-017-0993-9
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Springer Icon for Zurich Open Access Repository and Archive
Loading ...
Support Center