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Adv Exp Med Biol. 2017;1041:141-169. doi: 10.1007/978-3-319-69194-7_8.

Plasticity of the Muscle Stem Cell Microenvironment.

Author information

1
Biozentrum, University of Basel, Basel, Switzerland.
2
Biozentrum, University of Basel, Basel, Switzerland. christoph.handschin@unibas.ch.

Abstract

Satellite cells (SCs) are adult muscle stem cells capable of repairing damaged and creating new muscle tissue throughout life. Their functionality is tightly controlled by a microenvironment composed of a wide variety of factors, such as numerous secreted molecules and different cell types, including blood vessels, oxygen, hormones, motor neurons, immune cells, cytokines, fibroblasts, growth factors, myofibers, myofiber metabolism, the extracellular matrix and tissue stiffness. This complex niche controls SC biology-quiescence, activation, proliferation, differentiation or renewal and return to quiescence. In this review, we attempt to give a brief overview of the most important players in the niche and their mutual interaction with SCs. We address the importance of the niche to SC behavior under physiological and pathological conditions, and finally survey the significance of an artificial niche both for basic and translational research purposes.

KEYWORDS:

Extracellular matrix; Muscle regeneration; Muscular dystrophies; Satellite cells; Skeletal muscle; Stem cell-niche

PMID:
29204832
PMCID:
PMC5850985
DOI:
10.1007/978-3-319-69194-7_8
[Indexed for MEDLINE]
Free PMC Article

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