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J Clin Transl Endocrinol. 2017 Nov 7;10:28-35. doi: 10.1016/j.jcte.2017.11.002. eCollection 2017 Dec.

Effect of a vitamin and mineral supplementation on glycemic status: Results from a community-based program.

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Pure North S'Energy Foundation, Suite 800, 326-11th S.W., Calgary, Alberta T2R 0C5, Canada.
Department of Economics, University of Calgary, 2500 University Dr. N.W., Calgary, Alberta T2N 1N4, Canada.
362 Heritage Medical Research Building, University of Alberta, Edmonton, Alberta T6G 2S2, Canada.



Diet is a major risk factor for type 2 diabetes mellitus. As cofactors necessary for enzyme function of all metabolic pathways, vitamins and minerals have the potential to improve glucose metabolism. We investigated the effects of a nutrient intervention program on glycemic status.


We used a form of natural experiment to compare Pure North program participants (n = 1018) that received vitamin D alone (Vital 1) or vitamin D in combination with other nutrients (Vital 2) during two different time periods. Changes in 25-hydroxyvitamin D [25(OH)D], high-sensitivity C reactive protein (hs-CRP), glycated hemoglobin (HbA1c) and glycemic status were characterized over one and two years.


Serum 25(OH)D concentrations increased significantly in both Vital 1 (to 111  ±  49 nmol/L) and Vital 2 (to 119  ±  52 nmol/L) over one year. HbA1c and hs-CRP were significantly reduced over time in Vital 2. Higher 25(OH)D levels after one year were associated with larger decreases in HbA1c and hs-CRP in Vital 2. At one year, 8% of Vital 2 and 16% of Vital 1 participants progressed from normoglycemia to prediabetes/diabetes, whereas 44% of Vital 2 and 8% of Vital prediabetes/diabetes subjects regressed to normoglycemia.


Vitamin D combined with other nutrients was associated with a reduced risk of progression to diabetes and with an increased rate of reversion to normoglycemia in high risk participants. The results suggest that nutrient supplementation regimes may provide a safe, economical and effective means for lowering diabetes risk. Further examination of this potential via randomized controlled trials is warranted.


Multivitamin; Normoglycemia; Nutritional supplements; Prediabetes; Type 2 diabetes mellitus; Vitamin D

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