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J Clin Transl Endocrinol. 2017 Oct 13;10:22-27. doi: 10.1016/j.jcte.2017.10.001. eCollection 2017 Dec.

Beneficial effects of oral pure caffeine on oxidative stress.

Author information

1
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, University Hospital Policlinico G. Martino, Padiglione G, Messina, Italy.
2
Department of Clinical and Experimental Medicine, University of Messina, University Hospital Policlinico G. Martino Padiglione C, Via Consolare Valeria, 98100 Messina, Italy.
3
Department of Clinical and Experimental Medicine, University of Messina, Italy.
4
Master Program on Childhood, Adolescent and Women's Endocrine Health, University of Messina, Italy.
5
Interdep Program of Molecular & Clinical Endocrinology and Women's Endocrine Health, University Hospital Policlinico G. Martino, Padiglione H, Messina, Italy.

Abstract

Ingestion of coffee (which is a mixture of over 1000 hydrosoluble substances) is known to protect from type-2 diabetes mellitus and its complications, and other chronic disorders associated with increased oxidative damage in blood and tissues. This protection is generally attributed to polyphenols and melanoidins. Very few studies were conducted on the amelioration of classic blood markers of oxidative stress induced after a few days of caffeine administration, but results vary. To assess whether caffeine per se could account for antioxidant properties of coffee in the short-term, we tested the ability of pure caffeine ingestion (5 mg/kg body weight/day in two daily doses for seven consecutive days) to improve plasma levels of six biochemical indices in healthy male volunteers (n = 15). These indices were total antioxidant capacity (TAC), glutathione (GSH), oxidized glutathione (GSSG), GSH to GSSG ratio, lipid hydroperoxides (LOOH) and malondialdehyde (MDA). We found that all indices changed significantly (P < .05 or < .01) in a favourable manner, ranging from -41% for GSSG to -70% for LHP levels, and +106% for GSH levels to +249% for the GSG/GSSG ratio. Changes of any given index were uniform across subjects, with no outliers. We conclude that caffeine has unequivocal, consistent antioxidant properties.

KEYWORDS:

Caffeine; Coffee; Gluthathione; Lipid peroxidation; Malondialdehyde; Oxidative stress

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