Non ictal onset zone: A window to ictal dynamics

Pegah Afra; Sara J Hanrahan; Spencer Sterling Kellis; Paul House

doi:10.1016/j.ebcr.2017.10.003

Non ictal onset zone: A window to ictal dynamics

Epilepsy Behav Case Rep. 2017 Oct 21:8:123-127. doi: 10.1016/j.ebcr.2017.10.003. eCollection 2017.

Authors

Pegah Afra¹, Sara J Hanrahan², Spencer Sterling Kellis³, Paul House⁴

Affiliations

¹ Department of Neurology, School of Medicine, University of Utah, Salt Lake City, UT, United States.
² Colorado Neurological Institute, Englewood, CO, United States.
³ Division of Biology, Caltech, Pasadena, CA, United States.
⁴ Department of Neurosurgery, School of Medicine, University of Utah, Salt Lake City, UT, United States.

Abstract

The focal and network concepts of epilepsy present different aspects of electroclinical phenomenon of seizures. Here, we present a 23-year-old man undergoing surgical evaluation with left fronto-temporal electrocorticography (ECoG) and microelectrode-array (MEA) in the middle temporal gyrus (MTG). We compare action-potential (AP) and local field potentials (LFP) recorded from MEA with ECoG. Seizure onset in the mesial-temporal lobe was characterized by changes in the pattern of AP-firing without clear changes in LFP or ECoG in MTG. This suggests simultaneous analysis of neuronal activity in differing spatial scales and frequency ranges provide complementary insights into how focal and network neurophysiological activity contribute to ictal activity.

Keywords: Ictal dynamics; Ictal onset; Microelectrode array; Microgrid; Single neuron recording.

Publication types

Case Reports