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J Hum Genet. 2018 Feb;63(2):125-131. doi: 10.1038/s10038-017-0351-5. Epub 2017 Dec 4.

Genetic engineering in nonhuman primates for human disease modeling.

Author information

1
Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki-shi, 210-0821, Japan.
2
Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki-shi, 210-0821, Japan. esasaki@ciea.or.jp.
3
Advanced Research Center, Keio University, Shinjuku-ku, Tokyo, 160-8582, Japan. esasaki@ciea.or.jp.

Abstract

Nonhuman primate (NHP) experimental models have contributed greatly to human health research by assessing the safety and efficacy of newly developed drugs, due to their physiological and anatomical similarities to humans. To generate NHP disease models, drug-inducible methods, and surgical treatment methods have been employed. Recent developments in genetic and developmental engineering in NHPs offer new options for producing genetically modified disease models. Moreover, in recent years, genome-editing technology has emerged to further promote this trend and the generation of disease model NHPs has entered a new era. In this review, we summarize the generation of conventional disease model NHPs and discuss new solutions to the problem of mosaicism in genome-editing technology.

PMID:
29203824
DOI:
10.1038/s10038-017-0351-5
[Indexed for MEDLINE]

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