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Clin Sci (Lond). 2017 Dec 4;131(24):2865-2883. doi: 10.1042/CS20171246. Print 2017 Dec 15.

Oxidative stress and reactive oxygen species: a review of their role in ocular disease.

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Save Sight Institute, University of Sydney, Sydney, NSW 2000, Australia.
Westmead Institute for Medical Research, University of Sydney, Sydney, NSW 2145, Australia.
Department of Diabetes, The Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia.
Save Sight Institute, University of Sydney, Sydney, NSW 2000, Australia


For many years, oxidative stress arising from the ubiquitous production of reactive oxygen species (ROS) has been implicated in the pathogenesis of various eye diseases. While emerging research has provided some evidence of the important physiological role of ROS in normal cell function, disease may arise where the concentration of ROS exceeds and overwhelms the body's natural defence against them. Additionally, ROS may induce genomic aberrations which affect cellular homoeostasis and may result in disease. This literature review examines the current evidence for the role of oxidative stress in important ocular diseases with a view to identifying potential therapeutic targets for future study. The need is particularly pressing in developing treatments for conditions which remain notoriously difficult to treat, including glaucoma, diabetic retinopathy and age-related macular degeneration.


diabetic retinopathy; glaucoma; ocular disease; oxidative stress; reactive oxygen species; uveitis

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