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EBioMedicine. 2017 Dec;26:17-24. doi: 10.1016/j.ebiom.2017.11.024. Epub 2017 Nov 26.

Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal.

Author information

1
Department of Internal Medicine I, Division of Hematology & Hemostaseology, Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria. Electronic address: peter.valent@meduniwien.ac.at.
2
Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, MI, USA.
3
LBPA CNRS UMR8113, Ecole Normale Supérieure de Cachan, Cachan, France.
4
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
5
Department of Pathology, University of New Mexico, Albuquerque, NM, USA.
6
Department of Pathology and Stanford Center for Genomics and Personalized Medicine, Stanford University School of Medicine, Stanford, CA, USA.
7
Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
8
MLL Munich Leukemia Laboratory, Munich, Germany.
9
Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
10
Imagine Institute Université Paris Descartes, Sorbonne, Paris Cité, Centre national de référence des mastocytoses, Paris, France.
11
Department of Internal Medicine I, Division of Hematology & Hemostaseology, Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria.
12
Department of Pathology, Medical University of Vienna, Austria; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria,; Institute of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria.
13
Institute of Pathology, Hannover Medical School, Hannover, Germany.
14
Department of Medicine, Division of Hematology, Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
15
Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD, USA.
16
Servicio Central de Citometria, Centro de Investigacion del Cancer and Department of Medicine, University of Salamanca, Spain.
17
Department of Hematology and Oncology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.
18
Institute of Pathology, Paracelsus Medical University Salzburg, Salzburg, Austria.
19
Division of Hematology/Oncology, Department of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA.
20
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
21
Institute of Pathology, Ludwig-Maximilian University, Munich, Germany.

Abstract

Cancer evolution is a step-wise non-linear process that may start early in life or later in adulthood, and includes pre-malignant (indolent) and malignant phases. Early somatic changes may not be detectable or are found by chance in apparently healthy individuals. The same lesions may be detected in pre-malignant clonal conditions. In some patients, these lesions may never become relevant clinically whereas in others, they act together with additional pro-oncogenic hits and thereby contribute to the formation of an overt malignancy. Although some pre-malignant stages of a malignancy have been characterized, no global system to define and to classify these conditions is available. To discuss open issues related to pre-malignant phases of neoplastic disorders, a working conference was organized in Vienna in August 2015. The outcomes of this conference are summarized herein and include a basic proposal for a nomenclature and classification of pre-malignant conditions. This proposal should assist in the communication among patients, physicians and scientists, which is critical as genome-sequencing will soon be offered widely for early cancer-detection.

KEYWORDS:

Cancer; Clonal evolution; Neoplastic stem cells; Pre-malignant states

PMID:
29203377
PMCID:
PMC5832623
DOI:
10.1016/j.ebiom.2017.11.024
[Indexed for MEDLINE]
Free PMC Article

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