Format

Send to

Choose Destination
Trends Biochem Sci. 2018 Jan;43(1):4-9. doi: 10.1016/j.tibs.2017.11.001. Epub 2017 Dec 5.

The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation.

Author information

1
Department of Biochemistry, University of Toronto, Toronto, Ontario M5G 1M1, Canada; Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada. Electronic address: walid.houry@utoronto.ca.
2
IGMM, CNRS, Université de Montpellier, Montpellier, France; Equipe labélisée Ligue Nationale Contre le Cancer, IGMM - CNRS UMR5535, 1919 route de Mende, 34293 Montpellier 5, France. Electronic address: edouard.bertrand@igmm.cnrs.fr.
3
Translational Proteomics Research Unit, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec H2W 1R7, Canada; Département de biochimie et médecine moléculaire, Université de Montréal, Montréal, Québec H3T 1J4, Canada. Electronic address: benoit.coulombe@ircm.qc.ca.

Abstract

The Rvb1-Rvb2-Tah1-Pih1/prefoldin-like (R2TP/PFDL) complex is a unique chaperone that provides a platform for the assembly and maturation of many key multiprotein complexes in mammalian cells. Here, we propose to rename R2TP/PFDL as PAQosome (particle for arrangement of quaternary structure) to more accurately represent its unique function.

KEYWORDS:

R2TP; complex assembly; molecular chaperone; prefoldin; quaternary structure

PMID:
29203338
DOI:
10.1016/j.tibs.2017.11.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center