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Acta Med Iran. 2017 Sep;55(9):594-596.

Bowen's Disease Associated With Two Human Papilloma Virus Types.

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Department of Dermatology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Razi Clinico-Pathology Laboratory, Rasht, Iran.


Bowen's disease (BD) is an epidermal in-situ squamous cell carcinoma (SCC). Most Human Papilloma Viruses (HPV)-positive lesions in Bowen's disease are localized to the genital region or distal extremities (periungual sites) in which HPV type-16 is frequently detected. Patient was a 64-year-old construction worker for whom we detected 2 erythematous psoriasiform reticular scaly plaques on peri-umbilical and medial knee. Biopsy established the diagnosis of Bowen's disease and polymerase chain reaction assay showed HPV-6, -18 co-infection. Patient was referred for surgical excision.


Bowen's disease; Human papilloma virus; Squamous cell carcinoma

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