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Asian J Psychiatr. 2018 Feb;32:29-33. doi: 10.1016/j.ajp.2017.11.027. Epub 2017 Nov 29.

Association study of methylenetetrahydrofolate reductase genetic polymorphism 677C>T with schizophrenia in hospitalized patients in population of European Russia.

Author information

1
Russia. Electronic address: bizet@inbox.ru.
2
Research Institute of Preventive Medicine, Nizhny Novgorod State Medical Academy, 10/1 Minina and Pozharskogo sq., Nizhny Novgorod, 603005, Russia. Electronic address: sergeeva-av2013@yandex.ru.
3
Research Institute of Preventive Medicine, Nizhny Novgorod State Medical Academy, 10/1 Minina and Pozharskogo sq., Nizhny Novgorod, 603005, Russia. Electronic address: a.blagonravova@mail.ru.
4
Russia. Electronic address: kasimovaln@inbox.ru.
5
N.Ya. Klimova Nizhny Novgorod Regional Blood Center(1), 194 Rodionova st., Nizhny Novgorod, 603950, Russia.

Abstract

The purpose of the research was to investigate the association of methylenetetrahydrofolate reductase (hereinafter MTHFR) genetic polymorphism 677C>T with schizophrenia in the Russian population in comparison with the control group of healthy blood donors. Also some characteristics of schizophrenia were examined in patients with/without defective T-allele of MTHFR677C>T polymorphism. 500 patients with schizophrenia and 499 blood donors were examined for T-allele carriage of polymorphism MTHFR677C>T by PCR method. 150 archival medical records were studied (in the first patients included in the study). The carriage of T-allele of genetic polymorphism MTHFR677C>T was significantly more common in patients than in healthy donors: 255/500 versus 219/499 (p=0,0287, χ2=4,79; OR=1,33, 95%CI [1037; 1707]). The number of patients with chronic type of schizophrenia onset was significantly more among T-allele carriers (n=77) than among normal CC-genotype carriers (n=73): р=0.038. The number of "incapacitated" persons in the group of patients with defective T-allele (n=77) was significantly higher than in patients with normal genotype (n=73, p=0.0439; OR=2.878, 95%CI=1.111-7.456). The results suggest that T-allele of genetic polymorphism MTHFR677C>T in the population of European Russia may increase the risk of developing schizophrenia and its unfavorable prognosis, which requires further investigation.

KEYWORDS:

Folate deficiency; MTHFR 677C>T; Methylenetetrahydrofolate reductase genetic polymorphism 677C>T; Schizophrenia

PMID:
29202425
DOI:
10.1016/j.ajp.2017.11.027
[Indexed for MEDLINE]

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