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Public Health Action. 2017 Sep 21;7(3):237-239. doi: 10.5588/pha.17.0044.

Mental disorders and drug/alcohol use in patients commencing extensively drug-resistant tuberculosis treatment.

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Epsom and St Helier University Hospitals NHS Trust, London, UK.
Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Socios En Salud, Lima, Peru.
Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.


in English, French, Spanish

Mental disorders and alcohol/drug use worsen treatment outcomes for multidrug-resistant tuberculosis (TB), but data are lacking for extensively drug-resistant (XDR) TB. We investigated the association of baseline mental disorders and alcohol/drug use on XDR-TB treatment outcomes in a retrospective study of 53 XDR-TB Peruvian patients during 2010-2012. Logistic regression estimated the odds ratios for unfavourable XDR-TB treatment outcomes. Overall treatment success was 25%. Mental disorders and drug/alcohol use were found in respectively 22.4% and 20.4% of patients; neither were associated with unfavourable treatment outcomes. Future research should explore the relationship between mental health and drug/alcohol use in XDR-TB treatment outcomes.


XDR-TB; alcohol; anxiety; depression; psychosis

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