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Brain Behav. 2017 Oct 6;7(11):e00850. doi: 10.1002/brb3.850. eCollection 2017 Nov.

Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use.

Author information

1
Department of Psychiatry University of Alberta Edmonton AB Canada.
2
Department of Medicine University of Alberta Edmonton AB Canada.
3
Neuropsychology Alberta Hospital Edmonton AB Canada.
4
Department of Psychiatry Dalhousie University Halifax NS Canada.
5
Nova Scotia Early Psychosis Program Halifax NS Canada.
6
Edmonton Early Intervention in Psychosis Clinic Edmonton AB Canada.
7
Department of Medical Genetics University of Alberta Edmonton AB Canada.

Abstract

Objective:

COMT rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). We investigated the association between rs4680 and AoP, after adjusting for relevant covariates, in a Canadian Caucasian sample.

Methods:

One hundred and sixty-nine subjects with psychosis were recruited. AoP, defined as age of DSM-IV diagnosis was established using the Structured Clinical Interview for DSM-IV. Cannabis use data were collected using a self-report computerized questionnaire. DNA was extracted from saliva and genotyping of the COMT Val158Met polymorphism was done by SNaPshot and TaqMan assays. Logistic regression and Kaplan-Meier analysis results are reported.

Results:

In those who had used cannabis before 20 years of age, rs4680 had a trend level effect on AoP (median AoP: Val/Val < Val/Met < Met/Met 19.37, 20.95, 21.24 years, respectively; log-rank test = .051).

Conclusion:

Our data are indicative of the need to further investigate the association between the COMT rs4680 variant and AoP in the context of adolescent cannabis use.

KEYWORDS:

cannabis; catechol‐O‐methyltransferase; genes; psychotic disorders; sex

PMID:
29201551
PMCID:
PMC5698868
DOI:
10.1002/brb3.850
[Indexed for MEDLINE]
Free PMC Article

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