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Int J Med Sci. 2017 Oct 15;14(13):1360-1367. doi: 10.7150/ijms.17367. eCollection 2017.

Over-expression of Activated Signal Transducer and Activator of Transcription 3 Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma.

Li WM1,2,3,4, Huang CN1,2,3,5, Lee YC2,6, Chen SH1,2, Lin HH1,3, Wu WJ1,2,3,5,7,8, Li CC1,2,3,8, Yeh HC1,2,3,5,8, Chang LL2,9, Hsu WC1,2,3, Ke HL1,2,3.

Author information

1
Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
2
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
3
Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
4
Department of Urology, Ministry of Health and Welfare Pingtung Hospital, Pingtung, Taiwan.
5
Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan.
6
Department of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
7
Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan.
8
Department of Urology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.
9
Department of Microbiology, Kaohsiung Medical University, Kaohsiung, Taiwan.

Abstract

Background: Signal transducer and activator of transcription proteins (STATs) play important roles in gene regulation, cell proliferation, and cell differentiation. We aimed to establish the relationship between phosphorylated STAT3 (p-Ser-STAT3) expression and the prognosis of upper tract urothelial carcinoma (UTUC). Methods: This study retrospectively reviewed 100 patients with pathologically confirmed UTUC at Kaohsiung Medical University Hospital. We quantified the expression of p-Ser-STAT3 in cancer cells by immunohistochemistry, and determined the clinicopathological significance of p-Ser-STAT3 expression and prognostic outcomes in patients with UTUC. Results: High p-Ser-STAT3 expression was detected in 52% of UTUC patients. High p-Ser-STAT3 expression was associated with poor recurrence-free survival (p = 0.018) and overall survival (p = 0.026). In advanced cancer samples (stage T3/T4), p-Ser-STAT3 expression is the only independent prognostic factor for recurrence-free survival (hazard ratio = 5.91, p = 0.01) and cancer-specific survival (hazard ratio = 8.83, p = 0.039). Conclusions: The expression of p-Ser-STAT3 can be a potential prognostic marker for cancer recurrence and survival in UTUC, especially in advanced stage cases.

KEYWORDS:

Upper tract urothelial carcinoma; immunohistochemistry; prognosis; signal transducer and activator of transcription 3

PMID:
29200949
PMCID:
PMC5707752
DOI:
10.7150/ijms.17367
[Indexed for MEDLINE]
Free PMC Article

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