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Eur J Gastroenterol Hepatol. 2018 Feb;30(2):130-135. doi: 10.1097/MEG.0000000000001026.

Disruption of the gut-liver axis in the pathogenesis of acute-on-chronic liver failure.

Author information

1
The First Affiliated Hospital of Hu-Nan University of Chinese Medicine, Changsha.
2
Department of Microbiology and Immunologys.
3
The 302 Hospital of PLA, Treatment and Research Center for Infectious Diseases.
4
Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
5
Department of Medicine, Division of Infectious Diseases, Medical University of South Carolina, Charleston, South Carolina, USA.

Abstract

Acute-on-chronic liver failure (ACLF) is characterized by organ failure mediated by acute decompensation of cirrhosis. Recent studies have highlighted the importance of the gut-liver axis (GLS) and its association with ACLF pathogenesis. In this review, we discuss the mechanisms related to the alteration of the GLA and their involvement in ACLF pathogenesis and suggest some possible therapeutic options that could modulate the GLA dysfunction. This knowledge may provide information useful for the design of therapeutic strategies for gut dysbiosis and its complications in ACLF.

PMID:
29200007
PMCID:
PMC5738259
[Available on 2019-02-01]
DOI:
10.1097/MEG.0000000000001026
[Indexed for MEDLINE]

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