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Comp Biochem Physiol C Toxicol Pharmacol. 2018 Jun;208:12-19. doi: 10.1016/j.cbpc.2017.11.008. Epub 2017 Dec 1.

The neurological toxicity of heavy metals: A fish perspective.

Author information

1
Graduate Program in Toxicology, North Carolina State University, Raleigh, NC 27695, United States; Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, United States.
2
Graduate Program in Toxicology, North Carolina State University, Raleigh, NC 27695, United States; Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, United States; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC 27695, United States; W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, United States. Electronic address: ajplanch@ncsu.edu.

Abstract

The causes of neurodegenerative diseases are complex with likely contributions from genetic susceptibility and environmental exposures over an organism's lifetime. In this review, we examine the role that aquatic models, especially zebrafish, have played in the elucidation of mechanisms of heavy metal toxicity and nervous system function over the last decade. Focus is applied to cadmium, lead, and mercury as significant contributors to central nervous system morbidity, and the application of numerous transgenic zebrafish expressing fluorescent reporters in specific neuronal populations or brain regions enabling high-resolution neurodevelopmental and neurotoxicology research.

PMID:
29199130
PMCID:
PMC5936656
DOI:
10.1016/j.cbpc.2017.11.008
[Indexed for MEDLINE]
Free PMC Article

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