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ACS Infect Dis. 2018 Mar 9;4(3):315-324. doi: 10.1021/acsinfecdis.7b00183. Epub 2017 Dec 8.

Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii.

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Department of Chemistry , Vanderbilt University , 7330 Stevenson Center , Nashville , Tennessee 37235 , United States.
Department of Medicine , Vanderbilt University Medical Center , 1161 21st Avenue South, D-3100 Medical Center North , Nashville , Tennessee 37232 , United States.
Department of Pediatrics , Monroe Carell Jr. Children's Hospital at Vanderbilt , 2200 Children's Way, Suite 2404 , Nashville , Tennessee 37232 , United States.
Tennessee Valley Healthcare Systems , Department of Veterans Affairs , 1310 24th Avenue South , Nashville , Tennessee 37212 , United States.
Institute of Chemical Biology , Vanderbilt University , 896 Preston Research Building , Nashville , Tennessee 37232-6304 , United States.


In a previous study, we reported that human milk oligosaccharides (HMOs) isolated from five donor milk samples possessed antimicrobial and antibiofilm activity against Streptococcus agalactiae, also known as Group B Streptococcus or GBS. Herein, we present a broader evaluation of the antimicrobial and antibiofilm activity by screening HMOs from 14 new donors against three strains of GBS and two of the ESKAPE pathogens of particular interest to child health, Staphylococcus aureus and Acinetobacter baumannii. Growth and biofilm assays showed that HMOs from these new donors possessed antimicrobial and antibiofilm activity against all three strains of GBS, antibiofilm activity against methicillin-resistant S. aureus strain USA300, and antimicrobial activity against A. baumannii strain ATCC 19606.


A. baumannii; GBS; S. agalactiae; S. aureus; antibiofilm; antimicrobial

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