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Appl Microbiol Biotechnol. 2018 Jan;102(2):597-604. doi: 10.1007/s00253-017-8665-y. Epub 2017 Dec 2.

Bacterial perspectives on the dissemination of antibiotic resistance genes in domestic wastewater bio-treatment systems: beneficiary to victim.

Wu D1,2,3, Dolfing J4, Xie B5,6,7.

Author information

1
Shanghai Key Lab for Urban Ecological Processes and Eco-Restoration, School of Ecological and Environmental Science, East China Normal University, 500 Dong Chuan Road, Shanghai, 200241, China.
2
Shanghai Institute of Pollution Control and Ecological Security, Tongji University, 1239 Siping Road, Shanghai, 200062, China.
3
Joint Research Institute for New Energy and the Environment, East China Normal University and Colorado State University, Shanghai, 200062, China.
4
School of Civil Engineering and Geosciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
5
Shanghai Key Lab for Urban Ecological Processes and Eco-Restoration, School of Ecological and Environmental Science, East China Normal University, 500 Dong Chuan Road, Shanghai, 200241, China. bxie@des.ecnu.edu.cn.
6
Shanghai Institute of Pollution Control and Ecological Security, Tongji University, 1239 Siping Road, Shanghai, 200062, China. bxie@des.ecnu.edu.cn.
7
Joint Research Institute for New Energy and the Environment, East China Normal University and Colorado State University, Shanghai, 200062, China. bxie@des.ecnu.edu.cn.

Abstract

Domestic wastes, ranging from sewage and sludge to municipal solid waste, are usually treated in bioprocessing systems. These systems are regarded as main conduits for the elevated levels of antibiotic resistance genes (ARGs) observed in the environment. This paper mainly reviews recent studies on the occurrence and dynamics of ARGs in wastewater bio-treatment systems and discusses the ins and outs of ARG dissemination from the perspective of the microbial community. Our analysis shows that concentration of antibiotics through adsorption to microbial aggregates triggers the bacteria to acquire ARGs, which can be facilitated by the presence of mobile genetic elements. Notably, the acquisition and flow of ARGs during the rapid dissemination process is directed towards and for the best interests of the microbial community as a whole, and is influenced by surrounding nutrient levels, toxicant types, and sensitivities of the species in the prevailing antibiotic-stressed conditions. Furthermore, our review argues that predation of ARG-carrying bacteria by bacteriophages does periodically enhance the accessibility of ARGs to bacteria, which indirectly facilitates the recruitment of ARGs into environmental microbial communities.

KEYWORDS:

Antibiotic resistance dissemination; Antibiotic resistance genes; Domestic wastes; Waste bio-treatment

PMID:
29198067
DOI:
10.1007/s00253-017-8665-y
[Indexed for MEDLINE]

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