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Int J Cancer. 2018 Apr 15;142(8):1568-1579. doi: 10.1002/ijc.31187. Epub 2017 Dec 23.

Drivers of advanced stage at breast cancer diagnosis in the multicountry African breast cancer - disparities in outcomes (ABC-DO) study.

Author information

1
Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France.
2
Windhoek Central Hospital, Windhoek, Namibia.
3
Makerere University, Kampala, Uganda.
4
Federal Medical Centre, Owerri, Nigeria.
5
Abia State University Teaching Hospital, Aba, Nigeria.
6
University of North Carolina, Chapel Hill, USA.
7
University of the Witwatersrand, Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa.
8
Namibian Institute of Pathology, Windhoek, Namibia.
9
University Teaching Hospital, Lusaka, Zambia.
10
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
11
Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.

Abstract

Breast cancer (BC) survival rates in sub-Saharan Africa (SSA) are low in part due to advanced stage at diagnosis. As one component of a study of the entire journey of SSA women with BC, we aimed to identify shared and setting-specific drivers of advanced stage BC. Women newly diagnosed in the multicountry African Breast Cancer-Disparities in Outcomes (ABC-DO) study completed a baseline interview and their stage information was extracted from medical records. Ordinal logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for advanced stage (I, II, III, IV) in relation to individual woman-level, referral and biological factors. A total of 1795 women were included from Nigeria, Uganda, Zambia, and the multiracial populations of Namibia and South Africa, 1091 of whom (61%) were stage III/IV. Stage was lower in women with greater BC knowledge (OR 0.77 (95% CI: 0.70, 0.85) per point on a 6 point scale). More advanced stage was associated with being black (4.00 (2.79, 5.74)), having attended <secondary education (1.75 (1.42, 2.16)), having never heard of BC (1.64 (1.31, 2.06)), an unskilled job (1.77 (1.43, 2.20)) and pregnancy in the past 3 years (30% of ≤45 year olds) (1.63 (1.15, 2.31)), and were mediated through delays to diagnosis: symptom duration of ≥ 1 year (OR 2.47 (1.93, 3.15)). These findings provide further evidence that late-stage BC in SSA is largely attributed to modifiable factors and strategies to improve BC education and awareness in women and the health system should be intensified.

KEYWORDS:

breast cancer; stage at diagnosis; sub-Saharan Africa; survival

PMID:
29197068
PMCID:
PMC5838525
DOI:
10.1002/ijc.31187
[Indexed for MEDLINE]
Free PMC Article

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