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Methods Mol Biol. 2018;1710:347-352. doi: 10.1007/978-1-4939-7498-6_28.

A Randomized Double-Blinded Placebo-Controlled Intervention Trial of Melatonin for the Prevention of Preeclampsia in Moderate- and High-Risk Women: The MELPOP Trial.

Author information

1
Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Monash Medical Centre, Monash Health and Monash University, 246 Clayton Road, Clayton, VIC, 3168, Australia. sebastian.hobson@monash.edu.
2
Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Monash Medical Centre, Monash Health and Monash University, 246 Clayton Road, Clayton, VIC, 3168, Australia.
3
Maternal Fetal Medicine Division, Department of Obstetrics and Gynaecology, Mount Sinai Hospital and University of Toronto, 600 University Avenue, Toronto, ON, M5G 1X5, Canada.

Abstract

This chapter describes the methodologies which may be used in the development of a randomized controlled trial investigating a therapy of choice in preventing preeclampsia.

KEYWORDS:

Clinical trial; Melatonin; Oxidative stress; Preeclampsia; Prevention

PMID:
29197017
DOI:
10.1007/978-1-4939-7498-6_28
[Indexed for MEDLINE]

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