Format

Send to

Choose Destination
J Biol Chem. 2017 Dec 1;292(48):19605-19606. doi: 10.1074/jbc.H117.796383.

Stem cells take the stairs.

Vissers C1, Ming GL1,2,3, Song H4,2,3,5.

Author information

1
From The Graduate Program of Biochemistry, Cellular, and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 and.
2
the Department of Neuroscience and Mahoney Institute for Neurosciences.
3
The Institute for Regenerative Medicine, and.
4
From The Graduate Program of Biochemistry, Cellular, and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 and shongjun@pennmedicine.upenn.edu.
5
The Epigenetics Institute, Perelman School for Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

Abstract

Human embryonic stem cells progress through multiple stages in their path to neural differentiation, but the steps taken along the way are difficult to distinguish, limiting our understanding of this important process. Jing and colleagues (2) now report comprehensive analyses of transcriptome dynamics during this process that reveal five discrete stages, defined in part by highly connected transcription factor networks that link progressive stages. Surprisingly, the third stage, which appears to be critical for neural fate commitment, depends almost entirely on intracellular signaling.

PMID:
29196569
PMCID:
PMC5712602
DOI:
10.1074/jbc.H117.796383
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center