FcRn is mother's milk to allergen tolerance

J Exp Med. 2018 Jan 2;215(1):1-3. doi: 10.1084/jem.20172022. Epub 2017 Dec 1.

Abstract

In this issue Ohsaki et al. (https://doi.org/10.1084/jem.20171163) explain how breastfeeding can prevent the onset of food allergies in offspring by instructing T reg formation via neonatal Fc receptor (FcRn)-mediated transfer and uptake of allergen-containing IgG immune complexes (Ig-ICs) by gut dendritic cells (DCs).

Publication types

  • Comment

MeSH terms

  • Allergens*
  • Animals
  • Antigen-Antibody Complex*
  • Female
  • Food Hypersensitivity
  • Histocompatibility Antigens Class I
  • Immunoglobulin G
  • Milk
  • Mothers
  • Receptors, Fc

Substances

  • Allergens
  • Antigen-Antibody Complex
  • Histocompatibility Antigens Class I
  • Immunoglobulin G
  • Receptors, Fc