Atypical and Malignant Meningiomas: Neurooncologic Management in a Brazilian cohort

World Neurosurg. 2018 Feb:110:e20-e23. doi: 10.1016/j.wneu.2017.09.172. Epub 2017 Nov 28.

Abstract

Objective: To analyze the surgical and oncologic treatment of a Brazilian cohort of patients with grade II and III meningioma at a follow-up time of 15 years to get an overview of these patients' outcomes.

Methods: Cross-sectional study of 43 patients (26 women, 17 men; age range 20 to 83 years; average 57.72 ± 14.54) operated on from 2000 to 2014 at a single institution, with the neuropathologic diagnosis of meningioma grade II (39 patients) and grade III (4 patients).

Results: Radiotherapy: 24 patients (55.81%) underwent radiotherapy; the time between the surgical procedure and the beginning of radiotherapy was 5 months; 7 patients with a diagnosis of AM underwent a new surgical procedure, albeit of adjuvant therapy, because of tumor recurrence, and only 3 of them underwent radiotherapy after the first resection. Mortality: in total, 19 deaths (44.18%) were identified in this sample: 15 (38.46%) with GII and 4 (100%) with GIII. The 10-year survival was expected in 35% of GII patients and 0% of GIII patients.

Conclusion: Surgery is still the main form of treatment and the mainstay for prolonging survival. Radiotherapy is still controversial; however, we observed its positive impact on recurrence and progression-free survival.

Keywords: Atypical meningioma; Malignant meningioma; Progression-free survival.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brazil
  • Combined Modality Therapy
  • Cross-Sectional Studies
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Meningeal Neoplasms / mortality
  • Meningeal Neoplasms / pathology
  • Meningeal Neoplasms / radiotherapy*
  • Meningeal Neoplasms / surgery*
  • Meningioma / mortality
  • Meningioma / pathology
  • Meningioma / radiotherapy*
  • Meningioma / surgery*
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Recurrence, Local
  • Radiotherapy, Adjuvant
  • Retrospective Studies
  • Young Adult