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Ann Pathol. 2017 Dec;37(6):457-466. doi: 10.1016/j.annpat.2017.10.005. Epub 2017 Nov 28.

[FREGAT: French clinico-biological database dedicated to esogastric cancers].

[Article in French]

Author information

1
Institut de pathologie, centre de biologie pathologie génétique, University Lille, CHRU, 59000 Lille, France; UMR-S 1172-JPARC-centre de recherche Jean-Pierre-Aubert neurosciences et cancer, University Lille, 59000 Lille, France; Inserm, UMR-S 1172, 59000 Lille, France; SIRIC OncoLille, 59000 Lille, France.
2
Service d'anatomie et cytologie pathologiques, CHU de Caen, 14033 Caen, France.
3
Service de chirurgie oncologique et digestive, hôpital Huriez, university Lille, CHRU, 59000 Lille, France.
4
Département de recherche clinique, CHRU, 59000 Lille, France.
5
Centre de traitement des données du Cancéropôle Nord-Ouest, centre François-Baclesse, 14076 Caen cedex 5, France.
6
Service de cancérologie digestive, centre Oscar-Lambret, 59020 Lille, France.
7
UMR-S 1172-JPARC-centre de recherche Jean-Pierre-Aubert neurosciences et cancer, University Lille, 59000 Lille, France; Inserm, UMR-S 1172, 59000 Lille, France; SIRIC OncoLille, 59000 Lille, France; Service de chirurgie oncologique et digestive, hôpital Huriez, university Lille, CHRU, 59000 Lille, France. Electronic address: guillaume.piessen@chru-lille.fr.
8
UMR-S 1172-JPARC-centre de recherche Jean-Pierre-Aubert neurosciences et cancer, University Lille, 59000 Lille, France; Inserm, UMR-S 1172, 59000 Lille, France; SIRIC OncoLille, 59000 Lille, France; Service de chirurgie oncologique et digestive, hôpital Huriez, university Lille, CHRU, 59000 Lille, France.

Abstract

Even though esogastric cancers are estimated at 1.5 million new cases worldwide with an expected 2.11 million new cases by 2025, prognosis remains poor and research is unsatisfactory compared to other cancers. There is an urgent need to intensify research via innovative and ambitious programs to improve patient's survival and quality of life. Incidence of esogastric cancers is particularly high in France, and the creation of a national clinicobiological database prospectively collecting epidemiological, human and social, clinical, pathological, biological data, sustained by biobanks of blood and tissues, is a critical point to improve research and care for these cancers considering all determinants of the disease with a more integrated approach. FREGAT clinicobiological database, funded and labeled by the French NCI in 2012, gathers the vast majority of university hospitals and cancer centers in France. This research relies on preexisting networks ensuring its efficacy and quality. Beyond significant increase of inclusions opened since January 2015, the establishment of public multiprivate industrial partnerships and creation of numerous French and European scientific projects, make FREGAT a decisive tool for research on esogastric cancers.

KEYWORDS:

Base clinicobiologique; Biobanque nationale; Cancer de l’estomac; Cancer de l’œsophage; Clinico-biologic database; Esophageal cancer; Gastric cancer; National biobank; Recherche; Research

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