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Best Pract Res Clin Gastroenterol. 2017 Oct;31(5):529-536. doi: 10.1016/j.bpg.2017.09.001. Epub 2017 Sep 6.

Tobacco and alcohol as risk factors for pancreatic cancer.

Author information

1
Departments of Medicine, Biochemistry and Molecular Biology, Indiana University School of Medicine, The Melvin and Bren Simon Cancer Center and the Pancreatic Cancer Signature Center, Indianapolis, USA.
2
Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
3
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
4
Department of Surgery, University of Auckland, Auckland, New Zealand. Electronic address: max.petrov@gmail.com.

Abstract

Pancreatic cancer is projected to become the leading cause of cancer deaths by 2050. The risk for pancreatic cancer may be reduced by up to 27% by modifying lifestyle risk factors, most notably tobacco smoking. Based on analysis of more than 2 million unselected individuals from general population, this article quantified the risk of pancreatic cancer in relation to lifelong tobacco smoking and alcohol consumption status, both alone and in combination. It also provided a state-of-the-art review of animal studies on the effect of tobacco smoke and alcohol on genetically engineered mouse models of pancreatic precursor lesions, as well as the role of immune microenvironment in pancreatic carcinogenesis activated by tobacco and alcohol.

KEYWORDS:

Alcohol; Genetically engineered mouse models; Pancreatic cancer; Population risk; Tobacco

PMID:
29195672
PMCID:
PMC5747325
DOI:
10.1016/j.bpg.2017.09.001
[Indexed for MEDLINE]
Free PMC Article

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