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Rev Med Inst Mex Seguro Soc. 2017 Sep-Oct;55(5):568-574.

[Tamsulosin, oxybutynin or their combination in the treatment of ureteral stent-related symptoms].

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Servicio de Urología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México carlosgarciacruz1@gmail.com.

Abstract

in English, Spanish

BACKGROUND:

The aim of this paper is to compare the efficacy of tamsulosin, oxybutynin or their combination for the treatment of symptoms related to double J stent (DJS).

METHODS:

Randomized clinical non-blinded trial with three arms (tamsulosin, oxybutynin or combination) to assess the improvement of ureteral related symptoms with DJS with the questionnaire of Ureteral Stent Symptom Questionnaire (USSQ) and the adverse effects of treatment. Evaluations were made at 7 and 21 days after the placement of DJS. The maneuvers were compared using Chi squared test, Kruskall-Wallis, ANOVA and Wilcoxon considering a statistically significant p ≤ 0.05.

RESULTS:

170 patients with CJJ were evaluated. A perprotocol analysis was performed in 142 patients, 53 received tamsulosin (37.4%), 42 oxybutynin (29.6%) and 47 the combination of both (33%). At 7 and 21 days the improvement was similar in all three arms. Men with tamsulosin and women with oxybutynin had less general symptoms.

CONCLUSIONS:

Tamsulosin, oxybutynin or its combination similarly improve ureteral stent related symptoms and this improvement becomes more noticeable over time. Men are less symptomatic with tamsulosin and women with oxybutynin.

KEYWORDS:

Adrenergic alpha-antagonists; Cholinergic antagonists; Ureteral diseases; Urinary catheterization

PMID:
29193937
[Indexed for MEDLINE]

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