Review of the association between retinal microvascular characteristics and eye disease

Clin Exp Ophthalmol. 2018 Jul;46(5):531-552. doi: 10.1111/ceo.13119. Epub 2017 Dec 26.

Abstract

Computerized retinal imaging technologies enable the static and dynamic measurement of a range of retinal microvascular parameters. Large population-based studies have reported associations between these microvascular indices and various ophthalmic diseases including diabetes, age-related macular degeneration, retinal artery embolism, retinal vein occlusion, glaucoma and non-glaucomatous optic neuropathies. Increasingly, sophisticated imaging and analysis techniques have the potential to provide relevant clinical information regarding disease risk and progression; however, further studies are required to verify associations and strengthen the predictive power of these techniques. We summarize the current state of knowledge regarding retinal microvascular characteristics and eye disease.

Keywords: arteriole; retinal imaging; retinal vessel diameter; vascular disease; venule.

Publication types

  • Review

MeSH terms

  • Diagnostic Techniques, Ophthalmological*
  • Disease Progression
  • Eye Diseases / diagnosis*
  • Eye Diseases / physiopathology
  • Humans
  • Microvessels / diagnostic imaging*
  • Microvessels / physiopathology
  • Regional Blood Flow / physiology*
  • Retinal Vessels / diagnostic imaging*
  • Retinal Vessels / physiopathology