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Ann Intensive Care. 2017 Dec 1;7(1):115. doi: 10.1186/s13613-017-0337-7.

Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?

Author information

1
INSERM U1026, BioTis, Univ. Bordeaux, 33000, Bordeaux, France. antoine.dewitte@chu-bordeaux.fr.
2
Department of Anaesthesia and Critical Care II, Magellan Medico-Surgical Center, CHU Bordeaux, 33000, Bordeaux, France. antoine.dewitte@chu-bordeaux.fr.
3
INSERM U1026, BioTis, Univ. Bordeaux, 33000, Bordeaux, France.
4
Department of Pathology, CHU Bordeaux, 33000, Bordeaux, France.
5
Cell and Developmental Biology Department, Centre for Genomic Regulation, The Barcelona Institute for Science and Technology, 08003, Barcelona, Spain.
6
Department of Nephrology, Transplantation and Haemodialysis, CHU Bordeaux, 33000, Bordeaux, France.
7
Department of Anaesthesia and Critical Care II, Magellan Medico-Surgical Center, CHU Bordeaux, 33000, Bordeaux, France.
8
INSERM U1034, Biology of Cardiovascular Diseases, Univ. Bordeaux, 33600, Pessac, France.

Abstract

Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened the spectrum of their role in health and disease. Here, we propose a narrative review that first describes these new platelet attributes. We then examine their relevance to microcirculatory alterations in multi-organ dysfunction, a major sepsis complication. Rapid progresses that are made on the knowledge of novel platelet functions should improve the understanding of thrombocytopenia, a common condition and a predictor of adverse outcome in sepsis, and may provide potential avenues for management and therapy.

KEYWORDS:

Inflammation; Intensive care; Platelets; Sepsis

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