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Clin Nutr. 2018 Dec;37(6 Pt A):1943-1954. doi: 10.1016/j.clnu.2017.11.003. Epub 2017 Nov 16.

Effects of melatonin supplementation on blood lipid concentrations: A systematic review and meta-analysis of randomized controlled trials.

Author information

1
Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
2
Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
3
Department of Clinical Nutrition, Shiraz University of Medical Sciences, School of Nutrition and Food Sciences, Shiraz, Iran. Electronic address: zohreh.mazloom@gmail.com.

Abstract

BACKGROUND & AIMS:

Melatonin supplementation may be associated with blood lipids improvement; however, the current evidence from randomized controlled trials (RCTs) is inconsistent. The present study aimed to systematically review and analyze RCTs assessing the effects of melatonin supplementation on blood lipids.

METHODS:

A comprehensive literature search in several database was performed up to January 2017. Quantitative data synthesis was performed using a fixed or random-effects model, with weight mean difference (WMD) and 95% confidence intervals (CI). Standard methods were used for assessment of heterogeneity, meta-regression, sensitivity analysis and publication bias.

RESULTS:

A total of 8 RCTs were eligible. Meta-analysis suggested a significant association between melatonin supplementation and a reduction in triglycerides (WMD: -31.54 mg/dL, 95% CI: -50.71, -12.38, p = 0.001), and total cholesterol levels (WMD: -18.48 mg/dL, 95% CI: -35.33, -1.63, p = 0.032), while no significant effect on LDL-C (WMD: -2.37 mg/dL, 95% CI: -11.61, -6.86, p = 0.615) and HDL-C (WMD: 1.28 mg/dL, 95% CI: -0.66, 3.23, p = 0.197) was found. In sub-group analysis, a significant decrease in triglycerides was found at doses ≥8 mg/d and when trials last ≥8 weeks. In addition, a significant decrease of total cholesterol was found at doses ≥8 mg/d and when total cholesterol baseline levels were ≥200 mg/dL.

CONCLUSIONS:

Melatonin supplementation has significant effects on triglycerides and total cholesterol levels, which was more evident in higher dose and longer duration and also in a higher concentration of cholesterol levels. Further studies are required to determine the benefits of melatonin on lipid profile.

KEYWORDS:

Cholesterol; HDL-cholesterol; LDL-cholesterol; Melatonin; Triglycerides

PMID:
29191493
DOI:
10.1016/j.clnu.2017.11.003

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