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Trends Cell Biol. 2018 Jan;28(1):1-3. doi: 10.1016/j.tcb.2017.11.005. Epub 2017 Nov 27.

Heterotypic Ubiquitin Chains: Seeing is Believing.

Author information

1
Visiting scientist in the Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080, USA; Institute of Biochemistry II, Goethe University Frankfurt - Medical Faculty, University Hospital, 60590 Frankfurt am Main, Germany.
2
Institute of Biochemistry II, Goethe University Frankfurt - Medical Faculty, University Hospital, 60590 Frankfurt am Main, Germany; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt - Riedberg Campus, 60438 Frankfurt am Main, Germany. Electronic address: ivan.dikic@biochem2.de.

Abstract

The biological diversity of ubiquitination resides in the multivalent nature of linkage-specific homotypic and heterotypic ubiquitin (Ub) chains. A recent publication by Yau et al. in Cell describes the development of K11/K48-bispecific antibodies and a physiological role for K11/K48 heterotypic chains in regulation of the cell cycle and clearance of aggregated proteins.

KEYWORDS:

APC/C; Huntingtin (HTT); K11/K48 branched; heterotypic Ub chain; ubiquitin

PMID:
29191367
DOI:
10.1016/j.tcb.2017.11.005
[Indexed for MEDLINE]

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