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J Proteome Res. 2017 Dec 1;16(12):4253-4258. doi: 10.1021/acs.jproteome.7b00734.

Progress and Future Direction of Chromosome-Centric Human Proteome Project.

Author information

1
Yonsei Proteome Research Center and Department of Biochemistry, Yonsei University.
2
Centre for Blood Research, Departments of Oral Biological & Medical Sciences and Biochemistry & Molecular Biology, Faculty of Dentistry, University of British Columbia.
3
Institute for Systems Biology.
4
Advanced Clinical BioSystems Research Institute , Department of Medicine, Cedars-Sinai Medical Centre.
5
Departments of Computational Medicine & Bioinformatics, Internal Medicine, and Human Genetics and School of Public Health, University of Michigan.

Abstract

This special issue of JPR celebrates the fifth anniversary of the Chromosome-Centric Human Proteome Project (C-HPP). We present 27 manuscripts in four categories: (i) Metrics of Progress and Resources, (ii) Missing Protein Detection and Validation, (iii) Analytical Methods and Quality Assessment, and (iv) Protein Functions and Disease. We briefly introduce key messages from each paper, mostly from C-HPP teams and some from the Biology and Disease-driven HPP. From the first few months of the C-HPP NeXt-MP50 Missing Proteins Challenge, authors report 73 missing protein detections that meet the HPP guidelines using several novel approaches. Finally, we discuss future directions.

PMID:
29191025
DOI:
10.1021/acs.jproteome.7b00734
[Indexed for MEDLINE]

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