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J Mech Behav Biomed Mater. 2018 Feb;78:254-265. doi: 10.1016/j.jmbbm.2017.11.031. Epub 2017 Nov 21.

Effect of two-year degradation on mechanical interaction between a bioresorbable scaffold and blood vessel.

Author information

1
Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Epinal Way, Loughborough LE11 3TU, UK.
2
Abbott Vascular, 3200 Lakeside Drive, Santa Clara, CA 95054, USA.
3
Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Epinal Way, Loughborough LE11 3TU, UK. Electronic address: L.Zhao@Lboro.ac.uk.

Abstract

This paper aims to evaluate the mechanical behaviour of a bioresorbable polymeric coronary scaffold using finite element method, focusing on scaffold-artery interaction during degradation and vessel remodelling. A series of nonlinear stress-strain responses was constructed to match the experimental measurement of radial stiffness and strength for polymeric scaffolds over 2-year in-vitro degradation times. Degradation process was modelled by incorporating the change of material property as a function of time. Vessel remodelling was realised by changing the size of artery-plaque system manually, according to the clinical data in literature. Over degradation times, stress on the scaffold tended to increase firstly and then decreased gradually, corresponding to the changing yield stress of the scaffold material; whereas the stress on the plaque and arterial layers showed a continuous decrease. In addition, stress reduction was also observed for scaffold, plaque and artery in the simulations with the consideration of vessel remodelling. For the first time, the work offered insights into mechanical interaction between a bioresorbable scaffold and blood vessel during two-year in-vitro degradation, which has significance in assisting with further development of bioresorbable implants for treating cardiovascular diseases.

KEYWORDS:

Bioresorbable polymeric scaffold; Degradation; Finite element; Mechanical interaction; Vessel remodelling

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