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Rev Med Chil. 2017 Aug;145(8):1072-1075. doi: 10.4067/s0034-98872017000801072.

[Metformin-associated lactic acidosis. Report of one case].

[Article in Spanish]

Author information

1
Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile.
2
Unidad de Nefrología, Clínica Las Condes, Santiago, Chile.
3
Centro de Pacientes Críticos, Clínica Las Condes, Santiago, Chile.

Abstract

Metformin-associated lactic acidosis is a severe and infrequent adverse event. Early diagnosis is essential to start an early treatment, which often has favorable results. We report a 56 years old non-insulin-requiring type 2 diabetic female who developed a severe metabolic acidosis associated with metformin in relation to an acute renal failure secondary to infectious diarrhea. Early treatment with bicarbonate and continuous hemofiltration allowed a quick improvement of the patient. Metformin-associated lactic acidosis has an elevated mortality (50-80%) and has a specific and effective treatment. Therefore, the condition must be born in mind.

PMID:
29189867
DOI:
10.4067/s0034-98872017000801072
[Indexed for MEDLINE]
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