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J Biol Chem. 2018 Apr 13;293(15):5404-5413. doi: 10.1074/jbc.TM117.000117. Epub 2017 Nov 29.

Ubiquitin signaling and autophagy.

Author information

1
From the Institute of Biochemistry II, Goethe University Frankfurt-Medical Faculty, University Hospital, 60590 Frankfurt am Main and.
2
From the Institute of Biochemistry II, Goethe University Frankfurt-Medical Faculty, University Hospital, 60590 Frankfurt am Main and ivan.dikic@biochem2.de.
3
the Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt-Riedberg Campus, 60438 Frankfurt am Main, Germany.

Abstract

Ubiquitination is a widespread post-translational modification that controls multiple steps in autophagy, a major lysosome-mediated intracellular degradation pathway. A variety of ubiquitin chains are attached as selective labels on protein aggregates and dysfunctional organelles, thus promoting their autophagy-dependent degradation. Moreover, ubiquitin modification of autophagy regulatory components is essential to positively or negatively regulate autophagy flux in both non-selective and selective pathways. We review the current findings that elucidate the components, timing, and kinetics of the multivalent role of ubiquitin signals in control of amplitude and selectivity of autophagy pathways as well as their impact on the development of human diseases.

PMID:
29187595
PMCID:
PMC5900779
DOI:
10.1074/jbc.TM117.000117
[Indexed for MEDLINE]
Free PMC Article

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