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Anticancer Res. 2017 Dec;37(12):6871-6877.

Diagnostic Performance of Multiparametric Magnetic Resonance Imaging and Fusion Targeted Biopsy to Detect Significant Prostate Cancer.

Author information

1
Department of Nuclear Medicine, Johannes Gutenberg-University, Mainz, Germany manuhoffmann@web.de.
2
Bundeswehr Medical Service Headquarters, Supervisory Center for Medical Radiation Protection, Koblenz, Germany.
3
Praxis Urologie, Koblenz, Germany.
4
Bundeswehr Central Hospital, Department of Urology, Koblenz, Germany.
5
Radiologisches Institut Dr. von Essen, Koblenz, Germany.
6
Urologische Gemeinschaftspraxis, Koblenz, Germany.
7
German Air Force Center for Aerospace Medicine, Department of Epidemiology, Fürstenfeldbruck, Germany.
8
Department of Nuclear Medicine, Johannes Gutenberg-University, Mainz, Germany.

Abstract

BACKGROUND/AIM:

Multiparametric magnetic resonance imaging combined with ultrasound-fusion-targeted biopsy of the prostate intends to increase diagnostic precision, which has to be clarified.

PATIENTS AND METHODS:

We performed multiparametric magnetic resonance imaging followed by ultrasound-fusion-guided perineal biopsy in 99 male patients with elevated prostate-specific-antigen and previous negative standard biopsy-procedures.

RESULTS:

In 33/99 patients (33%) no malignancy could be confirmed by histopathology. Low-grade carcinomas (Gleason-Score 6+7a) were found in 42/66 (64%) and high-grade carcinomas (Gleason-Score ≥7b) in 24/66 (36%) men. A high-grade carcinoma corresponded to PI-RADS 4 or 5 (suspected malignancy) in 21/24 cases, which accounted for a sensitivity of 88% and negative-predictive-value of 85% (p=0.002). Differentiation between high-/low-grade carcinomas (Gleason-Score ≤7a vs. ≥7b) by means of PI-RADS related to a sensitivity of 88% and a negative-predictive-value of 70% (p=0.74).

CONCLUSION:

The results support the view that multiparametric magnetic resonance imaging/ultrasound-fusion-guided biopsy promotes considerably higher detection rates of clinically relevant prostate malignancies than do conventional diagnostic procedures. With regard to differentiation between high- and low-grade carcinomas, no significant difference was demonstrated.

KEYWORDS:

Magnetic resonance imaging; diagnostic imaging; prostatic neoplasms

PMID:
29187467
DOI:
10.21873/anticanres.12149
[Indexed for MEDLINE]

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