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BMC Infect Dis. 2017 Nov 29;17(1):735. doi: 10.1186/s12879-017-2840-8.

Identification of pathogens for differential diagnosis of fever with jaundice in the Central African Republic: a retrospective assessment, 2008-2010.

Author information

1
Institut Pasteur of Bangui, Virology Department, PO Box 923, Bangui, Central African Republic.
2
Institut Pasteur of Bangui, Epidemiology Service, PO Box 923, Bangui, Central African Republic. amanirak@yahoo.fr.
3
Hôpital de l'Amitié, Ministry of Public Health, Population and AIDS Control, PO Box 883, Bangui, Central African Republic.

Abstract

BACKGROUND:

Febrile jaundice results clinically in generalized yellow coloration of the teguments and mucous membranes due to excess plasma bilirubin, accompanied by fever. Two types are found: conjugated and unconjugated bilirubin jaundice. Jaundice is a sign in several diseases due to viruses (viral hepatitis and arbovirus), parasites (malaria) and bacteria (leptospirosis). In the Central African Republic (CAR), only yellow fever is included on the list of diseases for surveillance. The aim of this study was to identify the other pathogens that can cause febrile jaundice, for better management of patients.

METHODS:

Between 2008 and 2010, 198 sera negative for yellow fever IgM were randomly selected from 2177 samples collected during yellow fever surveillance. Laboratory analyses targeted four groups of pathogens: hepatitis B, C, delta and E viruses; dengue, chikungunya, Zika, Crimean-Congo haemorrhagic fever, West Nile and Rift Valley arboviruses; malaria parasites; and bacteria (leptospirosis).

RESULTS:

Overall, 30.9% sera were positive for hepatitis B, 20.2% for hepatitis E, 12.3% for hepatitis C and 8.2% for malaria. The majority of positive sera (40.4%) were from people aged 16-30 years. Co-infection with at least two of these pathogens was also found.

CONCLUSION:

These findings suggest that a systematic investigation should be undertaken of infectious agents that cause febrile jaundice in the CAR.

KEYWORDS:

Central African Republic; Differential diagnosis; Febrile jaundice

PMID:
29187150
PMCID:
PMC5707826
DOI:
10.1186/s12879-017-2840-8
[Indexed for MEDLINE]
Free PMC Article

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