Send to

Choose Destination
Cell Rep. 2017 Nov 28;21(9):2528-2540. doi: 10.1016/j.celrep.2017.11.001.

Lymphocytes Negatively Regulate NK Cell Activity via Qa-1b following Viral Infection.

Author information

Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany.
Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
Institute for Virology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen 45147, Germany.
Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address:


NK cells can reduce anti-viral T cell immunity during chronic viral infections, including infection with the lymphocytic choriomeningitis virus (LCMV). However, regulating factors that maintain the equilibrium between productive T cell and NK cell immunity are poorly understood. Here, we show that a large viral load resulted in inhibition of NK cell activation, which correlated with increased expression of Qa-1b, a ligand for inhibitory NK cell receptors. Qa-1b was predominantly upregulated on B cells following LCMV infection, and this upregulation was dependent on type I interferons. Absence of Qa-1b resulted in increased NK cell-mediated regulation of anti-viral T cells following viral infection. Consequently, anti-viral T cell immunity was reduced in Qa-1b- and NKG2A-deficient mice, resulting in increased viral replication and immunopathology. NK cell depletion restored anti-viral immunity and virus control in the absence of Qa-1b. Taken together, our findings indicate that lymphocytes limit NK cell activity during viral infection in order to promote anti-viral T cell immunity.


B cell; LCMV; NKG2A; NKreg; Qa-1b; anti-viral T cell; chronic viral infection

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center