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Molecules. 2017 Nov 29;22(12). pii: E2097. doi: 10.3390/molecules22122097.

Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates.

Author information

1
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. nick4780664@gmail.com.
2
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. jillj6jp6wn6@gmail.com.
3
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. scyang@kmu.edu.tw.
4
Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. scyang@kmu.edu.tw.
5
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. scyang@kmu.edu.tw.

Abstract

Given the importance of heterocycle indole derivatives, much effort has been directed toward the development of methods for functionalization of the indole nucleus at N1 and C3 sites. Moreover, the platinum-catalyzed allyation of nucleophiles was an established and efficient way, which has been applied to medicinal and organic chemistry. In our research, the platinum-catalyzed 2,3-disubstitued indoles with allylic acetates was investigated under different conditions. Herein, we established a simple, convenient, and efficient method, which afforded high yield of allylated indoles.

KEYWORDS:

allylation; allylic acetates; indole derivatives; platinum-catalyzed

PMID:
29186044
PMCID:
PMC6149942
DOI:
10.3390/molecules22122097
[Indexed for MEDLINE]
Free PMC Article

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