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Crit Rev Food Sci Nutr. 2017 Nov 29:1-10. doi: 10.1080/10408398.2017.1396201. [Epub ahead of print]

Lipid-modifying activity of curcuminoids: A systematic review and meta-analysis of randomized controlled trials.

Author information

1
a Biomedical Research Unit , Mexican Social Security Institute , Durango , Mexico.
2
b Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine , University of Perugia , Perugia , Italy.
3
c Weill Cornell Medical College , New York , NY , United States.
4
d Department of Hypertension , WAM University Hospital in Lodz, Medical University of Lodz , Zeromskiego 113, Lodz , Poland.
5
e Polish Mother's Memorial Hospital Research Institute (PMMHRI) , Lodz , Poland.
6
f Weill Cornell Medicine Qatar , Doha , Qatar.
7
g Sabinsa Corporation , East Windsor , NJ , United States.
8
h Biotechnology Research Center , Mashhad University of Medical Sciences , Mashhad , Iran.

Abstract

OBJECTIVE:

The aim of this systematic review and meta-analysis was to determine and clarify the impact of curcuminoids on serum lipid levels.

METHODS:

Randomized controlled trials (RCTs) investigating the effects of curcuminoids on plasma lipids were searched in PubMed-Medline, Scopus, Web of Science databases (from inception to April 3rd, 2017). A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on lipid concentrations.

RESULTS:

A meta-analysis of 20 RCTs with 1427 participants suggested a significant decrease in plasma concentrations of triglycerides (WMD: -21.36 mg/dL, 95% CI: -32.18, -10.53, p < 0.001), and an elevation in plasma HDL-C levels (WMD: 1.42 mg/dL, 95% CI: 0.03, 2.81, p = 0.046), while plasma levels of LDL-C (WMD: -5.82 mg/dL, 95% CI: -15.80, 4.16, p = 0.253) and total cholesterol (WMD: -9.57 mg/dL, 95% CI: -20.89, 1.75, p = 0.098) were not altered. The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation.

CONCLUSION:

This meta-analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels.

KEYWORDS:

Cardiovascular disease; Cholesterol; Curcumin; Dyslipidemia; Triglycerides; Turmeric

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