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ACS Chem Biol. 2018 Jan 19;13(1):53-59. doi: 10.1021/acschembio.7b00852. Epub 2017 Dec 4.

Design and Application of a DNA-Encoded Macrocyclic Peptide Library.

Author information

1
GlaxoSmithKline , 200 Cambridge Park Dr., Cambridge, Massachusetts 02140, United States.
2
GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.

Abstract

A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 × 1012 members composed of 4-20 natural and non-natural amino acids. Affinity-based selection was performed against two therapeutic targets, VHL and RSV N protein. On the basis of selection data, some peptides were selected for resynthesis without a DNA tag, and their activity was confirmed.

PMID:
29185700
DOI:
10.1021/acschembio.7b00852
[Indexed for MEDLINE]

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