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Transl Androl Urol. 2017 Oct;6(5):943-950. doi: 10.21037/tau.2017.09.01.

Amniotic therapeutic biomaterials in urology: current and future applications.

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1
Department of Surgery and Section of Pediatric Urology, University of Utah, Salt Lake City, Utah, USA.
2
Primary Children's Hospital, University of Utah, Salt Lake City, Utah, USA.
3
Department of Surgery and Division of Urology Section of Men's Health, University of Utah, Salt Lake City, Utah, USA.

Abstract

To examine the rationale and applications of amniotic tissue augmentation in urological surgery. Published literature in English-language was reviewed for basic science and clinical use of amniotic or amnion-chorionic tissue in genitourinary tissues. Basic science and animal studies support the likely benefit of clinical applications of amnion-derived tissues in a variety of urologic interventions. The broad number of properties found in amniotic membrane, coupled with its immunologically privileged status presents a number of future applications in the urological surgical realm. These applications are in their clinical infancy and suggest that further studies are warranted to investigate the use of these products in a systematic fashion.

KEYWORDS:

Amnion; chorion; dehydrated membranes; hypospadias; urethral reconstruction

Conflict of interest statement

Conflicts of Interest: William O. Brant: proctor, consultant, and grant recipient, Boston Scientific; Siam Oottamasathien: scientific advisory consultant, GlycoMira Therapeutics Inc. The other authors have no conflicts of interest to declare.

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